Sounds a bit like Lord Fanny from the Invisibles.

Equal Rites

Great book, Terry Pratchett was pretty prescient

It’s not about trans issues per se (that would be closer to Cheery Littlebottom’s storyline starting in Feet of Clay), but it is similar to the premise in this post.

The eighth son of the eighth son will always become a wizard. But what happens when the eighth son is a daughter?

I played in a campaign of Masks: The Next Generation, a teenage superhero tabletop RPG. Another player’s character was from a family where all the women had dark cosmic powers and were trained from when they were young girls to keep them under control. Their character was AMAB, and after coming out and transitioning found they had to deal with powers they were untrained in. Cool character concept.