The prime directive is a great example of how even a good rule taken to the extreme can end up causing more harm than good.
But beyond that, it’s just an easy aid for the writers to add a point of conflict for their stories. The prime directive as a value within the federation seems secondary to me.
I can recommend against enders. I have two friends with them, and one myself. Between the 3 of us none of them are currently working, and its been like this since i found out all 3 of us had 3d printers. Keeping them working is like pulling teeth.